Pharmacogenetic Scientific Bulletin
PHARMACOGENETIC is your genetic support in drug selection, drug dosage, interaction, side effect evaluation for your personalized treatment decision.
The drugs do not show the desired efficacy and the most important reason for drug-related side effects is that the drugs used are not suitable for the patient’s genetic nature.
The metabolism of drugs differs from person to person. This is due to the fact that the enzymes in the metabolism pathway of drugs are regulated by different genetic structures in each person. The same active ingredient causes different treatment results and side effects in each individual by showing less, more or normal activity compared to its slow, fast or normal metabolism in different people.
In all drug treatments applied, drugs are not effective enough in 40-70% of cases and 7-10% of patients experience side effects of the drugs. Every year, at least 2.2 million drug-related side effects occur in the USA, and more than 100,000 of them gets come to an end to death. The use of pharmacogenetic tests that show the effect or side effect of a drug on which patient reduces the incidence of side effects and the losses associated with them.
Pharmacogenetic tests are DNA analyzes performed to determine a patient’s response to drug therapy, toxicity, and drug interactions. It allows individualized treatment.
The health authority FDA in the United States of America and EMA in Europe require Pharmacogenetic information and special warnings in the prospectus of hundreds of the most commonly used drugs. When starting treatment with these drugs, dose adjustment specific to the individual’s genotype, clinical response variations and pharmacogenetic testing are required to determine the risk of side effects.
PHARMACOGENETIC DNA PANEL, It is carried out in the laboratory established by President of the European Pharmacogenetics Association Prof. Dr. Ron Van Schaik at Erasmus University in Rotterdam.
PHARMACOGENETIC DNA PANEL:
- Proper active ingredient selection,
- Determining the optimal dose,
- Determining drug interactions,
- Reducing the likelihood of side effects
- Increasing compliance with treatment
individualized treatment planning and application is possible.
The test procedure is easy and fast.
1) Oral epithelial sample is taken. There is no needle and blood sample.
2) The sample what taken is placed into a special kit.
3) It is protected with security barcodes and transmitted to the laboratory under appropriate conditions.
4) The result which including genetic consultation send in a short time.